??? 樊娜娜，中國科學(xué)院廣州生物醫(yī)藥與健康研究院，副研究員。2012年畢業(yè)于中國科學(xué)技術(shù)大學(xué)，獲理學(xué)博士學(xué)位。自研究生在讀期間，一直從事克隆豬及基因修飾豬研究工作，在世界上首次獲得了存活的iPS 克隆豬；參與完成了ZFN、TALEN、CRISPR/Cas9 技術(shù)在豬、兔基因打靶中的應(yīng)用研究及RAG基因免疫缺陷豬、TYR基因敲除白化豬模型和PARK2/PINK1雙基因敲除帕金森疾病模型豬等多種模型豬的建立；近年在Cell Research，Cell regeneration 等雜志發(fā)表文章13 篇，其中第一作者文章3 篇，通訊作者文章1篇，主持國家自然科學(xué)基金青年基金1項(xiàng)，參加國家自然科學(xué)基金、973項(xiàng)目、廣東省科技計(jì)劃等多項(xiàng)。
動物克隆與轉(zhuǎn)基因?
基因修飾人類疾病動物模型的建立?
1. Fan N, Chen J, Shang Z, Dou H, Ji G, Zou Q, Wu L, He L, Wang F, Liu K, Liu N, Han J, Zhou Q, Pan D, Yang D, Zhao B, Ouyang Z, Liu Z, Zhao Y, Lin L, Zhong C, Wang Q, Wang S, Xu Y, Luan J, Liang Y, Yang Z, Li J, Lu C, Vajta G, Li Z, Ouyang H, Wang H, Wang Y, Yang Y, Liu Z, Wei H, Luan Z, Esteban MA, Deng H, Yang H, Pei D, Li N, Pei G, Liu L, Du Y, Xiao L, Lai L. Piglets cloned from induced pluripotent stem cells. Cell Res. 2013 Jan;23(1):162-6. ?
2. Fan N, Lai L. Genetically modified pig models for human diseases. J Genet Genomics. 2013 Feb 20;40(2):67-73. ?
3. Wang Y#, Fan N#, Song J, Zhong J, Guo X, Tian W et al. Generation of knockout rabbits using transcription activator-like effector nucleases. Cell Regeneration, 2014, February, 3:3? #co-author?
4. Muti-gene targeting in rabbits using the Cas9/gRNA system. Yan Q, Zhang Q, Yang H, Zou Q, Tang C, Fan N*, Lai L*, Cell Regeneration. 2014 Sep 27;3(1):12.. * co-correspondence?
5. Zhou X, Xin J, Fan N, Zou Q, Huang J, Ouyang Z, Zhao Y, Zhao B, Liu Z, Lai S, Yi X, Guo L, Esteban MA, Zeng Y, Yang H, Lai L. Generation of CRISPR/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer. Cell Mol Life Sci. 2014 Oct 2. ?
6. Huang J, Guo X, Fan N, Song J, Zhao B, Ouyang Z, Liu Z, Zhao Y, Yan Q, Yi X, Schambach A, Frampton J, Esteban MA, Yang D, Yang H, Lai L. RAG1/2 knockout pigs with severe combined immunodeficiency. J Immunol. 2014 Aug 1;193(3):1496-503.?
7. Huang L, Fan N, Cai J, Yang D, Zhao B, Ouyang Z, Gu W, Lai L. Establishment of a porcine Oct-4 promoter-driven EGFP reporter system for monitoring pluripotency of porcine stem cells. Cell Reprogram. 2011 Apr;13(2):93-8.?
8. Xin J, Yang H, Fan N, Zhao B, Ouyang Z, Liu Z, Zhao Y, Li X, Song J, Yang Y, Zou Q, Yan Q, Zeng Y, Lai L. Highly efficient generation of GGTA1 biallelic knockout inbred mini-pigs with TALENs.?
PLoS One. 2013 Dec 17;8(12):e84250.?
